Npgrj_nn_1485 855..857
نویسندگان
چکیده
We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line–derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. AntiGDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells.
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ScienceDirect - Journal of Chromatography B, Volume 858, Issues 1-2, Pages 1-312 (15 October 2007)
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1 Information and Knowledge Engineering, Tottori University, Tottori 680-0945, Japan, [email protected], Tel +81-857-31-5220, Fax +81-857-31-0879 2 Graduated school, Tottori University, Tottori 680-0945, Japan, [email protected], Tel +81-857-31-5220, Fax +81-857-31-0879 3 Information and Knowledge Engineering, Tottori University, Tottori 680-0945, Japan, [email protected]....
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تاریخ انتشار 2005